MAC or Mycobacterium Avium Complex refers to an extremely rare but lethal defect of the immune system that allows an overwhelming systemic infection in affected dogs.
This disease was first noted in the 1990s and was thought to occur in a specific line of Miniature Schnauzers. While the numbers of affected dogs remains extremely low, it is considered a serious and lethal disease.
A DNA test has been developed and clinical research continues to be done by Dr. Urs Giger at the University of Pennsylvania, College of Veterinary Medicine and all cases are referred to his lab at the University.